1. Consumers perceive that OTC products are extremely safe and not likely to lead to serious toxicity. The marketing of OTC products emphasizes their safety and this perception may be reinforced by the availability of package sizes with large numbers of pills.
2. Consumers do not read the labels or follow the directions for use on OTC and prescription products.
3. Some of the prescription products are not adequately labeled to identify acetaminophen as an ingredient. Acetaminophen is often labeled as APAP on the prescription containers.
4. Consumers are not aware that acetaminophen can cause serious liver injury, in part because product labels do not adequately warn of this problem.
5. Consumers are not aware that acetaminophen is present in many OTC and prescription products and are not aware that they are exceeding the maximum daily dose.
6. Some populations (e.g., certain alcohol users and people with liver disease) are more susceptible to hepatic injury.
7. The symptoms of acetaminophen overdose may not appear for up to three days, so people may continue to take acetaminophen and increase the damage. The symptoms of liver injury may mimic the condition that they are treating (e.g., flu symptoms).
8. Because patients may not get adequate pain relief after taking the recommended dosage of acetaminophen, they may take more than the recommended amount or use other products that also contain acetaminophen.
9. Patients develop tolerance to narcotics and need to increase the dose of prescription combination products. If they do this on their own, they may not realize that they are increasing the dose of acetaminophen to toxic levels.
10. Combination narcotic products are commonly used because of limited non-narcotic options and greater restrictions on availability for higher scheduled single-ingredient narcotic analgesics.
For more information, please read the full report by The Acetominophen Hepatotoxicity Group.
References:
The Acetaminophen Hepatotoxicity Working Group Center for Drug and Evaluation Research, F. D. (2008). Recommendations for FDA Interventions to Decrease the Occurence of Acetaminophen Hepatotoxicity.
This is wonderful information. Is there a place online where we can check to make sure we are not taking medications that should not be taken at the same time. If I have a prescription from my doctor and then start taking something over the counter how do I know if they can be taken over the same period of time other than contacting my doctor to ask them?
ReplyDeleteCrystal Carlson
The information about acetaminophen was really interesting. I'll be looking at Tylenol differently from now on, haha.
ReplyDeleteThe consequences about the liver injury was surprising.
Crystal,
ReplyDeletePharmacists are valuable resources about possible interactions when purchasing your over-the-counter products. Make sure to READ THE LABELS of what you buy to make sure you know what you are taking and the risk associated with your prescriptions. You can also find valuable information about your specific medications on the FDA's website at www.fda.gov
Jibril,
The possibilities of liver damage through the use of acetominophen are not well known to consumers. Fortunately, you now have the ability to recognize serious drug effects such as these and avoid complications. Now that you're in the know, who else can benefit from this information? Maybe a friend, colleague, or those closest to you?
I found this information very helpful. Thank you for sharing it.
ReplyDeleteThis is valuable information. Until you are made aware of the trouble acetaminophen has on your liver, then you do not know how many over the counter products contain acetaminophen. It is troublesome that you may take some cold medicine and then a couple of excedrin for a headache and be putting yourself in jeopardy! Acetaminophen is NOT just in Tylenol! Thank you for such a comprehensive site!
ReplyDeleteThat is such a major part of the problem with acetaminophen toxicity- people don't realize they can overdose when taking multiple medications! It is shocking when you realize how serious this situation is!! Think of others you know who do not know this...Is there someone else who can benefit from this information?
ReplyDeleteGood information to know. It makes you think before popping a Tylenol/Advil before bedtime just for "maintenance". One never suspects that OTC's have the same danger of long-term side effects that prescription meds do.
ReplyDelete---M.Carr